Inflammatory breast cancer IBC is an uncommon type of invasive breast cancer that typically makes the skin on the breast look red and feel warm. It also may give the breast skin a thick, pitted appearance that looks a lot like an orange peel. These changes are caused by cancer cells blocking lymph vessels in the skin. Because inflammatory breast cancer has reached these vessels and has caused changes in the skin, it is considered to be at least a stage III breast cancer. IBC that has spread to other parts of the body is considered stage IV. These cancers typically grow quickly and can be challenging to treat.
Skip to Content. Use the menu to see other pages. This section explains the types of treatments that are the standard of care for inflammatory breast cancer. When making treatment plan decisions, you are encouraged to consider clinical trials as an option. A clinical trial is a research study that tests a new approach to treatment.
Electronic address: roberto. Inflammatory Breast Cancer IBC is a rare and very aggressive breast cancer, still associated with poor prognosis. Therefore, management of IBC requires carefully integrated care, and ideally, patients should be evaluated in a multidisciplinary team from the beginning, to identify the best treatment strategy.
This motivates interest in investigating whether varied approaches might be best to ensure LRC in this difficult circumstance. The radiation treatment dose and techniques described across series reporting IBC outcomes vary. The Memorial Sloan-Kettering Cancer Center reported similar local control without dose escalation but incorporating daily bolus 5. The University of Pennsylvania reports excellent local control among contemporary patients using bolus every other day 6. Because there will likely never be a randomized trial of PMRT dose escalation in IBC it is helpful to consider empirical recommendations and what general principles can be ascertained from these studies.