Woods has acted professionally since 1988. She is best known for portraying Deborah "Deb" Scott on the WB/CW teen drama series One Tree Hill. She starred in the show from 2003 to 2009 and appeared on the final season in 2012. She started out recurring in season 1 and was upgraded to full series regular status in November sweeps. Due to the format change of the show she only appeared in four episodes of season 5 but returned as a series regular in season 6.