The story revolves around Motu and Patlu, two friends living in Furfuri Nagar. The show focuses on how the two have a penchant to land themselves in comical situations, later rescuing themselves only by sheer luck. Samosas are Motu's favourite food, and he frequently tries to steal them from the local Chaiwala who makes the best samosas in the city. Motu is mainly the black sheep of the duo, unintentionally creating problems while Patlu is always the one to solve them. Sometimes, the characters Ghasitaram, Chingam and Dr. Jhatka aid them. However, Ghasitaram at times misdirects and swindles them by making them try Dr. Jhatka's vast repertoire of quirky gadgets and gizmos. After Motu eats samosas, he temporarily gains more energy and strength than he normally has.